By Johannes Ring
This publication provides the cutting-edge in learn into atopic dermatitis, or atopic eczema, and offers various powerful useful administration ideas which are grounded within the significant medical event of the writer. a systematic evidence-based method of the topic is followed, progressing from scientific signs in several ailment phases, molecular genetics, and pathophysiology via to therapy and prevention. All points of sufferer administration are coated, together with diagnostics, avoidance suggestions, emollient remedy, and acute therapy of eczema and itch. assorted distinctive healing methods are mentioned, starting from glucocorticoids, topical calcineurin inhibitors, and antimicrobial remedy via to UV remedy, allergen-specific immunotherapy, systemic immunosuppressive remedy, and rising strategies. Environmental impacts are thought of, and there's a specialize in the complete man or woman, with cognizance to psychosocial features of the ailment and the advantage of academic courses resembling “eczema schools”. Atopic Dermatitis could be important for dermatologists, allergists, pediatricians, and normal practitioners and informative for different individuals and sufferers.
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Extra info for Atopic Dermatitis: Eczema
We found a significant protective effect against the development of atopic respiratory diseases, especially bronchial asthma (Ring et al. 2004); after adjusting the East-West differences for the factor “pertussis vaccination,” the East-West differences observed earlier in respiratory airway disease disappeared. There was no influence of pertussis vaccination with regard to atopic eczema. Smallpox (Variola Vera) Until 30 years ago, the vaccination against smallpox with vaccinia antigen was considered a contraindication in individuals with atopic eczema because of the dramatic condition of “eczema vaccinatum” which represented a generalized blistering disease with possible life-threatening consequences.
2006b)) Atopic Eczema (%) 8 Total IgE (< 180 kU/l) 5,9 3,2 6 4 2 0,7 0,8 0,7 Only allergic against house dust mite Allergic against house dust mite plus grass pollen 0,7 0,7 3,9 1,1 1,7 1,6 Girls (n = 2418) Boys (n = 2333) 0 4,1 Only allergic against pollen 1 18 General Introduction and Epidemiology Thomas Bieber therefore postulated that atopic eczema always starts as an “intrinsic” condition, possibly on the basis of a disturbed skin barrier function (see Sect. 2) and that the IgE-mediated sensitizations only develop later in life (Bieber 2008; Fölster-Holst et al.
2 30 a Clinical Symptoms of Atopic Eczema b c d e Fig. 3 Erosive excoriated eczematous skin changes in atopic dermatitis. (a) Facial eczema in an infant. (b) Scaling hand and forearm eczema in an infant. (c) Diffuse erythematous excoriations in the face. (d) Marked erythematous flexural eczema in the elbow. (e) Punctate ero- f sive and excoriated skin changes in the knee joints. (f) Diffuse, partly nummular appearing erythemata with punctate erosions on the buttocks. (g) Massive facial eczema in an infant.
Atopic Dermatitis: Eczema by Johannes Ring