By Thomas R.E. Barnes and Peter Jenner (Eds.)

ISBN-10: 0120790351

ISBN-13: 9780120790357

Based on different volumes within the Neuroscience Perspectives sequence, this quantity covers the historical past, pharmacology, molecular biology, and biochemistry of antipsychotic medications, including an summary review of the healing issues. during the last forty years, the effectiveness of traditional neuroleptic brokers for psychotic disorder has been offset by means of quite a lot of antagonistic side-effects, together with motor side-effects like parkinsonism. experiences express that decreasing doses should produce the antipsychotic impression whereas lessening the danger of side-effects. As all on hand antispychotic medicines may be able to block dopamine, in particular D2 receptors, doses less than the brink point for generating acute motor disease can nonetheless be therapeutically potent. With the identity and characterization of a number of dopamine receptors, the opportunity of extra selective medicines with larger side-effect strength has arisen. different novel antipsychotic brokers comprise D1 receptor blockers, partial dopamine agonists and non-dopamine medications equivalent to 5-HT receptor blockers, sigma receptor antagonists and NMDA receptor agonists. This quantity stories either the fundamental technological know-how of the normal and peculiar neuroleptics and their current and strength healing use

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P. (1980) Br. J. Psychiat. 137, 379-386. , MacKie, M. H. (1984). Br. J. Psychiat. 144, 625-629. F. C. (1984) Molec. Cell. Endocrinol. 36, 201-209. Y. (1976) Schizophrenia Bull. 2, 106-135. Y. (1989) Psychopharmacology 99, S18-S27. Y. (1991) Schizophrenia Bull. 17, 263-287. M. & Kolakowska, T. J. ), pp. 255-279. , Trabucchi, M. et al. (1985) Brain Res. 347, 253-257. , Nishino, N. & Juno, T. (1986) Biol. Psychiat. 21, 1407-1414. , Albus, M. étal. (1984)Psychopharmacology84,436-440. L. W. (1980) Endocrinology 106, 1795-1803.

Exp. Ther. 194, 37-46. 1 Blockade of 'D 2 -like' Receptors. 2 Selective Dopamine Depolarization Block Conclusion and Future Trends 45 47 47 48 52 53 56 57 57 58 59 Introduction Despite beneficial effects in the individual patient and positive influences in psychiatry, the neuroleptics used in the treatment of schizophrenia have two conspicuous deficiencies: ANTIPSYCHOTIC DRUGS AND THEIR SIDE-EFFECTS ISBN 0-12-079035-1 Copyright © 1993 Academic Press Limned All rights of reproduction in any form reserved J.

This could contribute to clozapine's differential effects within the nigrostriatal and mesolimbic systems, since it would explain why combining classical neuroleptics with anticholinergic agents, which reverse drug-induced depolarization blockade of A9 neurons, still fails to mimic the long-term neurological profile of clozapine. On the other hand, the failure of clinically relevant doses of clozapine to induce dopaminergic supersensitivity in animal studies or tardive dyskinesia in man could be related to the degree of D2 receptor occupancy never reaching a critical level (possibly > 70%) beyond which compensatory mechanisms and, eventually, decompensation come in to play.

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Antipsychotic Drugs and their Side-Effects by Thomas R.E. Barnes and Peter Jenner (Eds.)

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