By Professor and Chair Dr Yunbo Li

ISBN-10: 161209466X

ISBN-13: 9781612094663

It is a booklet that takes a different method of integrating wisdom in antioxidants from necessities to advances, and from uncomplicated learn to medical purposes. This ebook provides medical details on antioxidants in an organised, cogent, and in-depth demeanour. The constant layout of writing, the full-colour illustrations, and the great checklist of references make the ebook available and interesting. in addition to its price as a textbook for undergraduate and graduate scholars in lifestyles technology, "Antioxidants in Biology and medication" can also be an invaluable reference for biomedical examine scientists, clinicians, and different health and wellbeing execs.

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Extra info for Antioxidants in Biology and Medicine: Essentials, Advances, and Clinical Applications

Example text

All three isozymes catalyze dismutation of superoxide to hydrogen peroxide and molecular oxygen with a similar reaction rate constant. SOD isozymes play an important role in protecting against various disease processes in animal models, including cardiovascular diseases, diabetes, neurodegeneration, and cancer. This notion from another angle demonstrates a crucial involvement of superoxide in disease pathophysiology. Studies in human subjects also provide evidence indicating protective effects of SODs in certain disease conditions.

J. 2009;422:313-320. [40] Muller FL, Song W, Liu Y, Chaudhuri A, Pieke-Dahl S, Strong R, et al. Absence of CuZn superoxide dismutase leads to elevated oxidative stress and acceleration of agedependent skeletal muscle atrophy. Free Radic. Biol. Med. 2006;40:1993-2004. [41] Bivalacqua TJ, Armstrong JS, Biggerstaff J, Abdel-Mageed AB, Kadowitz PJ, Hellstrom WJ, et al. Gene transfer of extracellular SOD to the penis reduces O2-. and Superoxide Dismutase [42] [43] [44] [45] [46] [47] [48] [49] [50] [51] [52] [53] 45 improves erectile function in aged rats.

In addition, Cu,ZnSOD catalyzes tyrosine nitration by peroxynitrite [4]. However, the in vivo significance of these reactions remains to be elucidated. 2. Molecular Regulation A number of transcription factors have been shown to play a role in regulating constitutive or inducible expression of SOD genes. These transcription factors include NF- B, AP-1, AP-2, SP1, and CCAAT-enhancer-binding protein (C/EBP) [5]. Recently, it has been shown that Nrf2 regulates Cu,ZnSOD expression via an antioxidant response element-driven mechanism [6].

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Antioxidants in Biology and Medicine: Essentials, Advances, and Clinical Applications by Professor and Chair Dr Yunbo Li


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