By A. K. Szakal, Z. F. Kapasi, S. T. Haley (auth.), Marie H. Kosco-Vilbois (eds.)
Follicular dendritic cells (FOe) are particular between cells of the immune method. whereas their morphological features re sulted of their inclusion as a 'dendritic phone type', tt1ey fluctuate rather considerably from the opposite individuals of the dendritic mobile kin. not like T-cell-associated dendritic cells or the Langerhans cells present in the surface, FOe live in hugely prepared B telephone follicles inside secondary lymphoid tissues. This web site of resi dence supplied a nomenclature committee in 1982 with the second one descriptive issue for the derivation in their identify. The cardinal function of FOe is to catch and keep antigen at the floor in their dendritic tactics for prolonged quantities of time and it truly is this selection that gives the conceptual compo nent for the name of this booklet. in accordance with an antigenic problem, fundamental B cellphone follicles suffer dynamic occasions, giving upward thrust to germinal facilities that are linked to activation, enlargement, and differentiation methods of B cells. The interactions of B cells with Foe and T cells within the germinal facilities are crucial for producing the total repertoire of antibody isotypes received in the course of an antibody reaction. additionally, stimuli both initiated or major tained throughout the germinal middle reponse ends up in construction of excessive affinity antibodies in the course of the approaches of somatic muta tion and clonal choice. during this context, FOe act as a pivotal resource of antigen. They gather international proteins (e. g.
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Extra info for An Antigen Depository of the Immune System: Follicular Dendritic Cells
J11 D (CD24) appears as a cell adhesion molecule expressed on immature Band T cells (KADMON et al. 1992). According to TSIAGBE et al. 1992), the J11 D-rich cells may terminally differentiate into antibody-forming cells and thus never reach the centers. , to be published) germinal center cells expressing high J11 D, especially the dark zone. Since these cells are very sensitive to apoptosis and do not express homing receptors, they may degenerate during the experimental procedure or be unable to home to centers or to migrate because they adhere to other cells.
Reduced Bcl-2 expression after immune stimulation may render cells prone to apoptosis. This could be a mechanism for controlling cell numbers by removing unwanted cells, for example after recovery from an infection or another stimulus (AKBAR et al. 1993). Overexpression of Bcl-2 in transgenic mice extends the secondary immune response and prolongs the survival of memory cells (NUNEZ et al. 1991). Such mice display numerous antibody-secreting cells 75 days after secondary immunization, by which time only baseline levels are detected in normal mice.
Since these cells are very sensitive to apoptosis and do not express homing receptors, they may degenerate during the experimental procedure or be unable to home to centers or to migrate because they adhere to other cells. Thus, we still need cell markers to clearly identify the germinal center precursors. 12 Germinal Center T Cells Germinal centers develop in response to T-dependent antigens. Nu/nu or thymectomized mice exhibit practically no germinal centers (JACOBSON et al. 1974; GROSCURTH 1980b; KROESE 1987).
An Antigen Depository of the Immune System: Follicular Dendritic Cells by A. K. Szakal, Z. F. Kapasi, S. T. Haley (auth.), Marie H. Kosco-Vilbois (eds.)