By Ahcene Boumendjel, Jean Boutonnat, Jacques Robert

ISBN-10: 0470227346

ISBN-13: 9780470227343

A finished evaluation of the most up-tp-date medical examine on ABC transporters and multidrug resistanceATP-binding cassette transporter genes (ABC transporters) are identified to play an important function within the improvement of multidrug resistance (MDR). MDR is the facility of pathologic cells, resembling tumors, to resist chemical compounds designed to focus on and damage such cells. In MDR, sufferers who're on medicine finally improve resistance not to basically the drug they're taking, yet to a number of varieties of drugs.ABC Transporters and Multidrug Resistance deals a necessary source for pharmaceutical researchers who're operating to find medications to counteract multidrug resistance in ailments comparable to melanoma. in a single complete quantity, this ebook includes a selection of the most up-tp-date wisdom at the involvement of ABC transporters in drug shipping and resistance.This entire quantity offers an outline at the description of the constitution, the genome, common tissue expression, physiological element, and mechanism of motion of the ABC protein. The specialist members discover the expression, detection, and implications of ABC proteins in hematological malignancies and sturdy tumors and ABC proteins and pathogenic microorganisms. This quantity additionally explains MDR modulation via inhibition of ABC transporters and the layout of inhibitors and mechanism of motion. furthermore, the e-book deals crucial details at the organic and scientific point of multidrug resistance.

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Extra info for ABC Transporters and Multidrug Resistance (Wiley Series in Drug Discovery and Development)

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Biochim Biophys Acta 455: 152–162. 7. Gottesman MM and Ling V. 2006. The molecular basis of multidrug resistance in cancer: The early years of P-glycoprotein research. FEBS Lett 580: 998–1009. 8. Loo TW and Clarke DM. 2005. Recent progress in understanding the mechanism of P-glycoprotein-mediated drug efflux. J Membr Biol 206: 173–185. 9. Vaalburg W, Hendrikse NH, Elsinga PH, Bart J, and van Waarde A. 2005. P-glycoprotein activity and biological response. Toxicol Appl Pharmacol 207: 257–260. 10.

4. 1. Multi-Molecule Transporter As previously mentioned, P-gp was originally identified in resistant tumor cells as part of the mechanism of MDR; but over the last decade, it has been demonstrated that P-gp is also expressed throughout the body to confer intrinsic resistance to the tissues by exporting unnecessary or toxic exogenous substances or metabolites (135). It is thought that MDR substrates enter the cell through the lipid bilayer by passive diffusion and bind reversibly to P-gp in the bilayer or on the cytoplasmic side of the cell membrane.

Biochemistry 39: 194–204. 33. Ohga T, Uchiumi T, Makino Y, Koike K, Wada M, Kuwano M et al. 1998. Direct involvement of the Y-box binding protein YB-1 in genotoxic stress-induced activation of the human multidrug resistance 1 gene. J Biol Chem 273: 5997–6000. 34. Johnson RA, Ince TA, and Scotto KW. 2001. Transcriptional repression by p53 through direct binding to a novel DNA element. J Biol Chem 276: 27716– 27720. 35. Zhan M, Yu D, Lang A, Li L, and Pollock RE. 2001. Wild type p53 sensitizes soft tissue sarcoma cells to doxorubicin by down-regulating multidrug resistance-1 expression.

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ABC Transporters and Multidrug Resistance (Wiley Series in Drug Discovery and Development) by Ahcene Boumendjel, Jean Boutonnat, Jacques Robert


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